Profhilo Structura is the newest innovation in the Profhilo family. While the classic version treats the skin, Structura targets the fat tissue (adipose tissue) underneath. It is
2. Lifting Effect: By strengthening the deep structure, it pulls the face upwards and defines the jawline.
Profhilo is an award-winning, injectable anti-aging treatment made from ultra-pure Hyaluronic Acid. It is not a filler; it is a Bio-Remodeling agent that stimulates collagen and elastin to tighten sagging skin. At our Nişantaşı, Istanbul clinic, we use the specialized BAP (5-Point) Technique for maximum results with minimal downtime.
What Is Profhilo? (Injectable Skincare)
Think of Profhilo as a super-powerful moisturizer that works from the inside out. It contains one of the highest concentrations of Hyaluronic Acid on the market (64mg), stabilized without chemical cross-linking agents (BDDE-free) using patented NAHYCO® Technology.
The Result: It spreads like honey under the skin, treating the entire face rather than just filling a specific line.
How Does It Work?
Profhilo does not just hydrate; it remodels the aging tissue.
1. Stimulates: It wakes up your skin cells (fibroblasts) to produce 4 different types of Collagen and Elastin.
2. Tightens: It improves skin laxity (sagging) on the face, neck, and body.
3. Hydrates: It attracts water to the deep layers of the skin, creating a “dewy” look.
The Procedure: BAP Technique (5 Points)
We use the Bio Aesthetic Points (BAP) technique. Instead of multiple injections all over the face, we
inject specific boluses into 5 strategic points on each side of the face.
● Why? These points ensure the product spreads evenly across the entire face, minimizing
pain and the risk of bruising.
Who Is It For?
● Anyone noticing skin laxity (sagging) or dullness.
● Patients who want to avoid the “puffy” look of dermal fillers.
● Ideal for treating difficult areas like the Neck, Hands, and Arms.
● Suitable for all ages (prevention in 30s, repair in 40s+).
Treatment Protocol
1. Sessions: 2 sessions are recommended, spaced 4 weeks apart.
2. Maintenance: Results last for 6–9 months. A single maintenance session is recommended every
6 months to keep the “glow.”
Frequently Asked Questions
1. Is Profhilo a Filler? No. Fillers stay where they are injected to add volume and change facial
shape. Profhilo spreads under the skin to improve skin quality and tightness. It will not make your
face look puffy or round.
2. Is it painful? It is very comfortable compared to traditional mesotherapy. We use the BAP
(5-Point) Technique, meaning only 5 injection points per side. With numbing cream, discomfort is
minimal.
3. What is the best age to start?
● In your 30s: It acts as preventative care, maintaining the skin’s glow and collagen levels.
● In your 40s and beyond: It acts as a corrective treatment, tightening sagging skin and
restoring elasticity.
4. What is Profhilo Structura? It is a specialized version designed to support the superficial fat
pads of the face. It provides a “Lipolifting” effect, ideal for patients with hollow cheeks or more
advanced sagging. We will choose the best version for you during consultation.
5. Can it treat the Neck and Hands? Yes. Profhilo is considered the gold standard for treating
horizontal neck lines (“Tech Neck”) and rejuvenating the thin skin on the back of the hands.
6. Is there any downtime? Minimal. You may have small bumps (like mosquito bites) at the injection
points, which usually disappear within 12–24 hours as the product spreads underneath the skin. You
can return to work immediately.
7. Can I combine it with Botox? Yes. Botox relaxes dynamic wrinkles, while Profhilo improves the
overall skin texture. They work perfectly together for a complete rejuvenation.
8. Is it safe? Yes. Profhilo uses ultra-pure Hyaluronic Acid without chemical cross-linking agents
(BDDE-free), making it highly biocompatible with a very low risk of adverse reactions.
9. What is the cost in Istanbul? Prices depend on the area treated (Face, Neck, Body) and the
number of sessions. Treatment in Turkiye offers premium European quality at a competitive price.
PN (Polynucleotide) represents the “Gold Standard” in regenerative medicine. Derived from Salmon DNA, these long-chain molecules are certified as Class III Medical Devices, ensuring superior safety and potency compared to standard cosmetics. It is the preferred protocol in our Nişantaşı, Istanbul clinic for treating dark circles, neck lines, and skin laxity without artificial volume.
What Is PN Therapy?
While PDRN repairs the surface, PN builds the structure. It creates a 3D biological scaffold within the skin, stimulating fibroblasts to produce high-quality collagen.
Why Choose PN?
● Deep Regeneration: Reaches deeper layers than PDRN.
● Lifting Effect: Its high viscosity provides a natural tightening effect.
● Medical Safety: Being a Class III Medical Device, it meets the strictest safety regulations for injectables.
Where Does It Work Best?
1. Under-Eyes It thickens the dermis to hide dark circles and veins, without the risk of water retention (edema) common with HA fillers.
2. Neck & Décolleté Effectively targets deep horizontal lines (“Tech-Neck”) and restores skin density.
3. Full Face Lifting Tightens pores and lifts sagging skin, creating a firm and youthful texture.
The Procedure in Istanbul
1. Application: Performed using micro-injections or a cannula after numbing cream. Takes 20 minutes.
2. Protocol: We recommend 3 sessions, spaced 2–3 weeks apart, for a complete biological reset.
Frequently Asked Questions (FAQ)
1. Is PN better than PDRN ? Yes, for structural aging. PN is the stronger, medical-grade evolution of
PDRN. If you need lifting and deep repair, PN is the superior choice.
2. Is it a Filler? No. It does not add artificial volume. It restores your skin’s own volume by
regenerating tissue. You will look like “you,” just fresher.
3. What does “Class III” mean? It means the product is not just a cosmetic serum but a certified
Medical Device authorized for deep injection. This guarantees purity, sterility, and efficacy.
4. When will I see results? Texture improves after the first session. Significant lifting and elasticity
improvements are visible after the 2nd session and peak around month 3.
5. What is the cost in Istanbul? Prices depend on the brand (e.g., Plinest, Newest) and number of
sessions. Treatment in Turkey offers premium medical aesthetics at a competitive price.
Plinest and Newest are advanced biostimulators based on Polynucleotide (PN) technology derived from Salmon DNA. They serve to regenerate skin
at the cellular level. At our Nişantaşı, Istanbul clinic, we utilize Plinest Eye for dark circles, Plinest for deep repair, and Newest for intense hydration and glow.
What Is the Plinest Family? (PN Technology)
As we age, our skin’s DNA repair capacity diminishes. The Plinest family uses Polynucleotides (PN) to signal skin cells to “repair and regenerate.” Unlike standard
mesotherapy, it doesn’t just nourish; it biologically stimulates fibroblasts to restore skin structure.
The Product Range & Indications
Dr. Ömer Fatih Şahin selects the specifically tailored product based on your skin concern:
1. Plinest (Classic): “The Restorer”
Contains the highest concentration of Polynucleotides. It comes in a 2ml syringe and contains 40 mg of PN.
● Target: Deep tissue repair and firming.
● Best For: Acne scars, enlarged pores, stretch marks, and loss of elasticity. It aims to thicken and strengthen the skin.
2. Plinest Eye: “The Eye Specialist”
Designed to support regeneration in thin and sensitive periocular skin. It comes in a 2ml syringe and contains 15 mg of PN.
● Target: Eye area restructuring.
● Best For: Dark circles, puffiness, fine lines, and “tired eyes.” It is a safe biological alternative for those avoiding under-eye fillers.
3. Newest: “The Glow Booster”
A powerful combination of Polynucleotides (PN) + Hyaluronic Acid (HA) + Mannitol. It comes
in a 2ml syringe and contains 20 mg PN and 20 mg HA.
● Target: Repair + Intense Hydration.
● Best For: Dry, dull skin, and the neck/décolleté area. It provides an immediate
“moisture bomb” effect for a radiant glow.
The Procedure in Istanbul
1. Application: Performed using micro-injections or a cannula after applying numbing cream. The session takes about 15–20 minutes.
2. Protocol: We typically recommend 3 to 4 sessions, spaced 2–3 weeks apart, depending on skin condition.
Frequently Asked Questions (FAQ)
1. Can I have this if I have a fish allergy? The products are derived from salmon DNA.
Although highly purified, we generally do not recommend it for patients with severe fish
allergies as a precaution.
2. Is it a Filler? Will my face look swollen? No. None of these products add artificial
volume. Your face will not look swollen or changed. They simply improve the quality,
firmness, and health of your skin.
3. What is the difference between Newest and Plinest?
● Plinest: Pure PN. Focuses on firming and scar repair.
● Newest: PN + Hyaluronic Acid. Focuses on hydration and glow. Your doctor will
decide which one suits your skin type best.
4. When will I see results? You will feel hydration and skin relief after the first session.
Significant structural repair and pore tightening typically become visible after the 2nd
session.
5. Is there downtime? Minimal. You might have tiny bumps or minor bruising at the injection
sites for 24 hours. You can return to your social life immediately.
6. What is the cost in Istanbul? Prices depend on the specific product (Eye, Newest, etc.)
and the number of sessions. Treatment in Turkey offers premium quality at a competitive
price.
PDRN (Polydeoxyribonucleotide) is widely known as “Salmon DNA” and is used for surface skin healing and hydration. However, modern aesthetic medicine has evolved
towards PN (Polynucleotide) therapy. While PDRN is effective for mild hydration, our clinic primarily recommends Class III Medical Device certified PN treatments for true structural remodeling and anti-aging.
What Is PDRN?
PDRN consists of short DNA fragments derived from Salmon. It has been used for years to help heal diabetic wounds. In aesthetics, it is used as a “skin booster” to provide moisture and reduce redness.
How It Works: It binds to receptors on cells to lower inflammation and encourage mild healing. It gives the skin a temporary “fresh” look.
The Critical Difference: PDRN vs. PN
This is the most important distinction for patients to understand. In the medical world, the safety and potency of an injectable are defined by its classification.
1. PDRN (Short Chain): Often found in cosmetic mesotherapy cocktails. It nourishes the skin surface but lacks the strength to build structure. It is a “polishing” treatment.
2. PN (Polynucleotide – Long Chain): This is the purified, high-molecular-weight, and Class III Medical Device certified evolution of PDRN. When injected, it acts like a scaffold, lifting the tissue and stimulating deep collagen production.
Summary: PDRN is the “bandage,” PN is the “architect.”
Who Should Choose PDRN?
If you are not looking for deep anti-aging or lifting, but simply want to refresh your skin, PDRN might be an option:
● Superficial dryness and dullness.
● Mild redness or sensitive skin conditions.
● Entry-level skin maintenance.
However; for dark circles, neck lines, skin laxity (sagging), and deep acne scars, PN
(Polynucleotide) therapy is medically superior and more effective.
The Procedure in Istanbul
1. Application: PDRN is a fluid solution injected into the upper skin layers using mesotherapy techniques.
2. Comfort: It is a quick, 15-minute procedure with minimal discomfort using numbing cream.
3. Protocol: Usually requires 3-4 sessions spaced 2 weeks apart.
Frequently Asked Questions (FAQ)
1. Is PN better than PDRN? In most cases, yes. PN is the stronger, longer-lasting, and more
medically advanced version of PDRN. If you want a real biological investment in your skin structure,
Dr. Şahin recommends PN protocols (like Plinest/Newest).
2. Is PDRN a filler? No. It does not volumize the face. It only hydrates and soothes the skin.
3.3. Understanding Class III medical device classification and its clinical significance
Class III represents the highest safety standard for injectable medical devices in Europe and Turkey.
While many PDRN products are simple cosmetics, premium PN products are certified Medical
Devices, ensuring purity and safety.
4. How long do results last? PDRN results (glow and hydration) typically last 3–6 months. Since
PN rebuilds the tissue, its results can persist for 9–12 months.
5. Is there a price difference? Yes. PN products are more expensive due to their advanced
manufacturing technology and medical certification (Class III). However, they offer a much higher
value in terms of visible results and longevity.
(popularly known as “Paris Sparkle” in Turkey and “Chanel Injection” internationally) is a premium biorevitalization treatment containing 59 active ingredients
to nourish and illuminate tired skin. Applied using the painless NanosoftTM technology, it is the gold standard for treating dark circles and fine lines in our Nişantaşı, Istanbul clinic.
What Is NCTF 135 HA? (The “Chanel” of Mesotherapy)
Skin aging involves the loss of vital nutrients and radiance. NCTF 135 HA is a scientifically formulated “Cellular Nutrition” cocktail designed to replenish the dermis. Because of its premium ingredient list and the immediate “luxury glow” it provides, patients worldwide often refer to it as the “Chanel Injection.”
The Power of 59 Ingredients:
● Free Hyaluronic Acid: For deep hydration.
● 12 Vitamins & 24 Amino Acids: A comprehensive formulation containing essential vitamins and amino acids that support collagen and elastin synthesis.
● Coenzymes & Minerals: To speed up cellular repair.
● Objective: To achieve a brighter, tighter, and healthier skin texture.
Targeted Areas & Indications
This treatment is medically indicated for:
1. Dull & Tired Skin: To restore radiance and even out skin tone.
2. Eye Area (Nanosoft): To improve fine lines and reduce the appearance of dark circles.
3. Fine Wrinkles: To improve skin elasticity through deep hydration.
4. Pores: To refine skin texture.
The Procedure: NanosoftTM Technology
We utilize the NanosoftTM needle, which is three times smaller than a standard injection needle.
● Benefit: It allows precise delivery to sensitive areas like the eyelids and neck with minimal
discomfort and a significantly reduced risk of bruising.
Treatment Protocol
For optimal biological stimulation:
● Initial Course: 3 sessions, typically spaced 2 weeks apart.
● Maintenance: 1 session every 3–6 months to preserve the glow.
Frequently Asked Questions (FAQ)
1. Is NCTF 135 HA the same as Botox? No. Botox targets muscles to reduce dynamic wrinkles.
NCTF 135 HA nourishes the skin to improve its quality. They are different procedures that can
complement each other.
2. Can it be used on eyelids? Yes. The Nanosoft needle allows for safe application on the upper and
lower eyelids to target fine lines and skin quality in this delicate area.
3. Why is it called “Chanel Injection” or “Paris Sparkle”? These are popular nicknames. “Paris
Sparkle” highlights its French origin and the glow effect. “Chanel Injection” refers to its premium
status and high-quality formulation, widely used in South Korea and Europe.
4. Is there downtime? Minimal. Small bumps (papules) may appear on the skin immediately after the
procedure due to the injection technique. These typically resolve within 24 hours.
5. What is the cost in Istanbul? Treatment planning and pricing are determined based on individual
needs and treatment protocol. Treatment in Turkey offers access to this premium French
mesotherapy at a very competitive price compared to the UK or USA.
Ozone Therapy is a scientifically proven medical treatment that uses medical ozone gas (O3) to boost the immune system, improve blood circulation, enhance cellular oxygenation, and detoxify the body. In today’s world, stress and environmental toxins deplete our oxygen levels, leading to chronic fatigue and premature aging. At our clinic, Specialist Dr. Ömer Fatih Şahin, an Anesthesiologist with expertise in vascular access and safety, performs these treatments under strict sterile conditions.
How Does Ozone Work? (Biological Effects)
When introduced into the body, medical ozone acts as a “biological stressor” that triggers healing mechanisms:
1. Immune Activation: Stimulates white blood cells to fight infections.
2. Oxygenation: Improves the ability of red blood cells to release oxygen to tissues.
3. Metabolic Boost: Accelerates cellular metabolism and energy production.
4. Circulation: Improves blood flow and vascular health.
Which Method Is Right For You? (Application Types)
Ozone therapy is not a “one-size-fits-all” solution. Dr. Şahin applies different protocols depending on your specific needs and medical condition. Click on the titles below for detailed information:
1. Major Ozone Therapy (Systemic / Blood)
This is the most common “Gold Standard” method. Approximately 100cc of your blood is drawn, enriched with medical ozone in a sterile closed system, and returned to your body.
● Best For: General immunity boosting, anti-aging, chronic fatigue, and metabolic support.
● Click for Details
2. Multipass (High Dose) Ozone Therapy
An advanced, intensive version of Major Ozone. In a single session, the blood is treated and returned 3-5 times (passes) consecutively.
● Best For: Severe chronic fatigue, Lyme disease, autoimmune conditions, and patients seeking rapid recovery (Biohacking).
● Click for Details
3. Intra-Articular (Joint) Ozone
Direct injection of ozone gas into painful joints or muscle tissue to reduce inflammation and promote healing.
● Best For: Knee osteoarthritis (calcification), meniscus tears, rheumatic pain, and stubborn muscle stiffness.
● Click for Details
4. Rectal Ozone (Systemic Alternative)
Ideal for those with difficult veins, needle phobia, or children. Ozone gas is administered via the rectum (bowel), providing a systemic effect as powerful as blood ozone.
● Best For: Liver detox, Ulcerative Colitis/Crohn’s, and patients with poor vascular access.
● Click for Details
5. Vaginal Ozone Therapy (Women’s Health)
A localized application where ozone gas is administered to the vaginal area using a sterile applicator. It provides powerful disinfection and flora support.
● Best For: Recurrent vaginal yeast (Candida), persistent infections, Genital Herpes, and vaginal dryness.
● Click for Details
Frequently Asked Questions (FAQ)
● Question: Does it help with weight loss?
● Answer: While Ozone Therapy is not a magic weight loss tool, it significantly increases metabolic rate and improves cellular oxygenation. When combined with
diet and exercise, it can help accelerate fat burning and weight loss.
● Question: Can it support cancer treatment?
● Answer: It is not a cure for cancer. However, it is widely used as a complementary therapy to reduce the side effects of chemotherapy/radiotherapy and to boost the
body’s immune system (with oncologist approval).
● Question: Does it hurt?
● Answer: No. For Major Ozone, you only feel a small pinch when the IV is placed. The re-infusion of ozonated blood is painless.
● Question: Is it safe?
● Answer: Yes, when performed by a qualified doctor. However, patients with G6PD deficiency (Favism) or uncontrolled hyperthyroidism are not suitable candidates. Dr.
Şahin screens every patient before treatment.
Book Your Revitalization Session
To discover the benefits of Ozone Therapy, please contact us to schedule a consultation with Specialist Dr. Ömer Fatih Şahin.
Autologous Micrograft Hair Therapy (often known as Regenera Activa technology) is a revolutionary, single-session treatment for androgenetic alopecia (genetic hair loss). It utilizes “progenitor cells” harvested from your own healthy hair follicles to regenerate and thicken
thinning hair. For patients who are noticing hair thinning but are not ready for a full hair transplant, this is the most advanced medical solution available. At our clinic, Specialist Dr. Ömer Fatih Şahin performs this procedure with minimal invasiveness and maximum comfort.
The Science: Why Behind the Ear?
Hair follicles on the back of your head (occipital zone) are genetically resistant to hair loss hormones (DHT). Even in balding men, this area remains thick.
● The Method: We harvest tiny samples from this “strong zone.” We extract the powerful progenitor cells and growth factors.
● The Transfer: We inject this potent cocktail into the balding areas (top and front). The strong cells send signals to the weak cells, instructing them to “wake up” and grow thicker.
Who is the Ideal Candidate?
● Early to Moderate Hair Loss: Men and women seeing their scalp through their hair.
● Women: Especially effective for diffuse thinning (widening part line).
● Hair Transplant Patients: It is an excellent “booster.” It heals the donor area faster and increases the survival rate of the transplanted grafts.
● Busy Internationals: Perfect for tourists because it requires only one session (unlike PRP which needs 6).
Frequently Asked Questions (FAQ)
● Question: Does it work for Alopecia Areata (Patchy Hair Loss)?
● Answer: This treatment is primarily designed for Androgenetic Alopecia (Genetic
Hair Loss). Since Alopecia Areata is an autoimmune condition where the body
attacks hair follicles, the primary treatment usually involves stopping the immune
attack first. Dr. Şahin can recommend specific protocols for Areata during
consultation.
● Question: Is it a Hair Transplant?
● Answer: No. We do not move thousands of hairs. We move the “cells” that stimulate
hair growth. If you are completely bald, you need a transplant. If you have thinning
hair, Micrograft is the solution.
● Question: When will I see results?
● Answer: Since it is a biological process, patience is key.
● Month 1: Hair shedding decreases significantly.
● Month 3-4: Hair becomes visibly thicker and denser.
● Month 6: Full results are visible.
● Question: Will there be scars?
● Answer: No. The sampling sites are tiny and heal within days without stitches. They
are hidden by your existing hair.
Book Your Hair Restoration
To save your hair with the power of your own cells, please contact us to schedule a consultation with Specialist Dr. Ömer Fatih Şahin.
Autologous Micrograft Skin Therapy is a regenerative anti-aging treatment that harvests young, healthy fibroblast cells from behind your ear and transplants them into your face, neck, or décolletage. Unlike synthetic fillers that artificially volumize the face, this treatment focuses on Bio-Restructuring. It uses your own tissue to repair deep acne scars, smooth out fine lines, and restore the elasticity of your youth. Performed by Specialist Dr. Ömer Fatih Şahin, it is a one-session protocol with
long-lasting results.
Why Behind the Ear?
The donor area provides cells with higher biological activity compared to facial skin. These cells are carefully introduced into areas showing signs of aging to support natural skin regeneration.
● The Process: We act as biological gardeners. We take these “young & healthy” cells and plant them into the “aged & damaged” areas of your face.
● The Result: The transplanted cells start producing new Collagen Type-3 (Baby Collagen) and Elastin, naturally tightening the skin.
Perfect for Acne Scars & Aging
This technology fills the gap where lasers often fail:
1. Acne Scars: For deep, pitted scars (atrophic), lasers resurface the top, but Micrografts build the tissue from underneath, pushing the scar up and smoothing the skin.
2. Crepey Skin: Thickens thinning skin on the neck and hands.
3. Natural Anti-Aging: For patients who say “I don’t want to look fake or puffy.”
Frequently Asked Questions (FAQ)
● Question: Can I do this treatment in summer?
● Answer: Yes, absolutely. Unlike chemical peels or strong lasers that make your skin
sensitive to the sun, Autologous Micrograft therapy works beneath the surface. It
does not peel the top layer of your skin, so it is safe to perform even in sunny months
with standard sun protection.
● Question: Is it a Dermal Filler?
● Answer: No. Fillers are gels that add volume immediately. Micrograft is a cellular
therapy that builds your own tissue over time. It doesn’t change your face shape; it
changes your skin quality.
● Question: How long does it last?
● Answer: Since it regenerates your own tissue, the results are long-lasting. The aging
process continues naturally, but from a “rejuvenated” baseline. A maintenance
session can be done after 1-2 years.
● Question: Can I combine it with lasers?
● Answer: Yes. Combining Micrografts (to build tissue from inside) with Lasers (to
polish the surface) is the ultimate protocol for acne scars and severe aging.
Book Your Biological Facial
To regenerate your skin with the power of your own cells, please contact us to schedule a consultation with Specialist Dr. Ömer Fatih Şahin.
