Plinest and Newest are advanced biostimulators based on Polynucleotide (PN) technology derived from Salmon DNA. They serve to regenerate skin
at the cellular level. At our Nişantaşı, Istanbul clinic, we utilize Plinest Eye for dark circles, Plinest for deep repair, and Newest for intense hydration and glow.

What Is the Plinest Family? (PN Technology)
As we age, our skin’s DNA repair capacity diminishes. The Plinest family uses Polynucleotides (PN) to signal skin cells to “repair and regenerate.” Unlike standard
mesotherapy, it doesn’t just nourish; it biologically stimulates fibroblasts to restore skin structure.
The Product Range & Indications
Dr. Ömer Fatih Şahin selects the specifically tailored product based on your skin concern:
1. Plinest (Classic): “The Restorer”
Contains the highest concentration of Polynucleotides. It comes in a 2ml syringe and contains 40 mg of PN.
● Target: Deep tissue repair and firming.
● Best For: Acne scars, enlarged pores, stretch marks, and loss of elasticity. It aims to thicken and strengthen the skin.
2. Plinest Eye: “The Eye Specialist”
Designed to support regeneration in thin and sensitive periocular skin. It comes in a 2ml syringe and contains 15 mg of PN.
● Target: Eye area restructuring.
● Best For: Dark circles, puffiness, fine lines, and “tired eyes.” It is a safe biological alternative for those avoiding under-eye fillers.
3. Newest: “The Glow Booster”

A powerful combination of Polynucleotides (PN) + Hyaluronic Acid (HA) + Mannitol. It comes
in a 2ml syringe and contains 20 mg PN and 20 mg HA.
● Target: Repair + Intense Hydration.
● Best For: Dry, dull skin, and the neck/décolleté area. It provides an immediate
“moisture bomb” effect for a radiant glow.
The Procedure in Istanbul
1. Application: Performed using micro-injections or a cannula after applying numbing cream. The session takes about 15–20 minutes.
2. Protocol: We typically recommend 3 to 4 sessions, spaced 2–3 weeks apart, depending on skin condition.

Frequently Asked Questions (FAQ)
1. Can I have this if I have a fish allergy? The products are derived from salmon DNA.
Although highly purified, we generally do not recommend it for patients with severe fish
allergies as a precaution.
2. Is it a Filler? Will my face look swollen? No. None of these products add artificial
volume. Your face will not look swollen or changed. They simply improve the quality,
firmness, and health of your skin.
3. What is the difference between Newest and Plinest?
● Plinest: Pure PN. Focuses on firming and scar repair.
● Newest: PN + Hyaluronic Acid. Focuses on hydration and glow. Your doctor will
decide which one suits your skin type best.
4. When will I see results? You will feel hydration and skin relief after the first session.
Significant structural repair and pore tightening typically become visible after the 2nd
session.
5. Is there downtime? Minimal. You might have tiny bumps or minor bruising at the injection
sites for 24 hours. You can return to your social life immediately.
6. What is the cost in Istanbul? Prices depend on the specific product (Eye, Newest, etc.)
and the number of sessions. Treatment in Turkey offers premium quality at a competitive
price.