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Nucleofill Soft Plus (Eyes)

The skin around the eyes is the thinnest and most delicate on the body, making it the first area to betray signs of aging—fine lines, dark circles, and loss of elasticity. While traditional methods often focus on “filling” this space, modern aesthetic medicine prioritizes cellular repair. This is where Nucleofill Soft Plus (formerly known as Nucleofill Eyes), often called the DNA Glow, sets a new standard.
🧬 Polynucleotide (PN) Technology: Re-Coding Your Cells
Nucleofill Soft Plus is composed of high-purity Polynucleotide chains. These molecules act as biological messengers that stimulate fibroblast cells in the deeper layers of the dermis.
  • Bio-Stimulation: It signals the skin to resume its natural production of collagen and elastin.
  • Anti-Free Radical Protection: It actively neutralizes oxidative stress caused by environmental factors like UV rays and pollution.
  • Intracellular Hydration: Unlike surface moisturizers, it increases the water-binding capacity within the tissue, creating a “radiance from within.”
Why Choose Nucleofill Soft Plus Over Eye Fillers?
While many patients consider tear trough fillers, Nucleofill Soft Plus offers a critical edge in terms of safety and natural aesthetics:
  • No Tyndall Effect: Hyaluronic acid fillers injected into thin skin can sometimes cause a bluish or grayish shadow (Tyndall effect). Since Nucleofill is not a filler, this risk is non-existent.
  • Zero Edema Risk: Fillers can attract water and lead to persistent puffiness or swelling. Soft Plus improves the biological structure and supports natural lymphatic drainage.
  • Skin Quality vs. Volume: Instead of artificially inflating the area, it thickens the dermis, making the skin look naturally resilient and healthy.
👁️ Indications: What Does Nucleofill Soft Plus Solve?
  1. Dark Circles and Hollow Eyes
Most dark circles are caused by thinning skin that makes underlying vessels visible. Soft Plus acts as a “biological curtain” by thickening the dermis, effectively masking the vascular shadows.
  1. Crow’s Feet and Micro-Wrinkles
It smooths the “crepey” texture around the eyes by boosting structural proteins. Unlike Botox, it preserves your natural expressions while softening fine lines.
  1. Laxity and Early Eye Bags
When skin loses its grip, underlying fat pads can bulge, creating bags. Nucleofill tightens the periorbital envelope, holding the tissue more firmly in place.
📊 Biological Synergy: The Protocol
  • Sessions: Typically recommended as a series of 2 to 4 sessions, spaced 21 days apart.
  • Comfort Level: With topical numbing cream, the procedure is minimally invasive, involving only slight pinprick sensations.
  • Fast Recovery: You can return to social life immediately. Small, temporary bumps (papules) at the injection sites usually vanish within 24 hours as the product is absorbed.
Expert Note on Branding: The manufacturer has updated the name from Nucleofill Eyes to Nucleofill Soft Plus. While you may hear both terms in clinics, the high-quality polynucleotide formula remains the same.
❓ Frequently Asked Questions (FAQ)
Can Nucleofill Soft Plus be combined with Botox? Yes. While Botox relaxes the muscles to prevent deep wrinkles, Nucleofill improves the skin’s structural quality. This combination is highly recommended for total periorbital rejuvenation.
How long do the effects persist? Depending on lifestyle and skin condition, the cumulative benefits of a full protocol maintain their structural integrity for 6 to 12 months. An annual maintenance session is suggested.
Who is the ideal candidate? It is suitable for young adults with genetic dark circles, middle-aged patients seeing the first signs of crow’s feet, and older individuals with significant skin laxity.
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Nucleofill Strong Plus

As skin ages, it doesn’t just lose moisture; it begins to succumb to gravity, losing its luster and elasticity. While traditional methods often attempt to “fill” these gaps, Nucleofill Strong Plus (widely known as the DNA Glow) takes a different approach. It repairs the skin’s biological structure at a cellular level, creating a sophisticated, natural lifting effect without the use of traditional fillers.
The Highest Concentration: What is Nucleofill Strong Plus?
The “Strong Plus” variant is the most potent member of the Nucleofill family. It contains a high density of Polynucleotides (PN) at 25 mg/ml (50 mg total per 2ml syringe). This concentrated formula is specifically engineered for larger areas requiring structural support, such as the face, neck, and décolletage.
The Triple-Action Cellular Pathway:
  1. Cellular Induction (Rejuvenation): It targets fibroblast receptors to maximize Type-1 collagen production, reinforcing the skin’s internal scaffolding.
  2. Biological Lifting: It tightens the soft tissue, effectively “lifting” early signs of sagging and skin laxity.
  3. Antioxidant Neutralization: It acts as a free-radical scavenger, cleaning up DNA damage caused by UV rays, pollution, and oxidative stress.
Maximum Efficiency with the “5-Point Technique”
One of the most significant advantages of Nucleofill Strong Plus is the specialized Bio Aesthetic Points (BAP) injection method. By targeting 5 strategic points on each side of the face:
  • Homogeneous Diffusion: The product spreads evenly across the entire facial framework.
  • Minimal Recovery: Fewer injection points mean a drastically reduced risk of bruising or swelling.
  • Zero Downtime: Achieve a “refreshed and tight” look without altering your natural facial expressions or features.
When Should You Choose Nucleofill Strong Plus?
  1. Skin Laxity and Sagging
Ideal for cases where the jawline is losing definition or the facial oval is beginning to soften. It restructures the skin from within for a visibly firmer contour.
  1. Deep Dullness and Lack of Radiance
Effectively eliminates the “tired skin” look, providing a healthy, vibrant glow—this is why international patients frequently request it as the DNA Glow Treatment.
  1. Neck and Décolletage Wrinkles
It is remarkably effective for “Venus Rings” (horizontal neck lines) and dehydration in the chest area, regions often neglected by standard facial treatments.
  1. Scar and Texture Refinement
By triggering the skin’s innate repair mechanisms, it helps smooth out acne scars and irregular skin textures.
Nucleofill Strong Plus vs. Traditional Fillers
Feature
Nucleofill Strong Plus (PN)
Hyaluronic Acid Filler
Primary Goal
Cellular Repair & Tightening
Volume Restoration & Shaping
Volumizing Effect
None (Maintains natural look)
Instant Volume (Can be high)
Duration of Result
Cumulative cellular improvement
Immediate physical presence
Aesthetics
Preserves facial expressions
May alter expressions if overdone
Protocol and Cumulative Longevity
  • Session Intervals: Generally planned as 2 to 3 sessions spaced 2–3 weeks apart.
  • Social Life: You can return to your daily activities immediately. The 5-point technique ensures a very rapid recovery.
  • Duration: The improvement in cellular quality typically maintains its integrity for 9–12 months. To sustain the bio-regenerative effect, a single maintenance session every 6 months is recommended.
Frequently Asked Questions (FAQ)
Will Nucleofill Strong Plus make my face look puffy?
Absolutely not. Nucleofill is a biostimulator, not a filler. it does not add artificial volume; it simply tightens and rejuvenates sagging or dull tissue.
Is the procedure painful?
The treatment is very comfortable, thanks to the use of topical numbing creams and the streamlined 5-point injection technique.
What is the difference between Nucleofill Strong and Strong Plus?
The “Plus” version comes in a 2ml pre-filled syringe, allowing for a comprehensive treatment of larger areas (like the full face and neck simultaneously) with a higher total capacity of polynucleotides.
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Rejuran I (Rejuran Eye)

Commonly known as “Rejuran Eye,” Rejuran I is a specialized formulation of Polynucleotides (PN) derived from wild salmon DNA. It is specifically designed for the delicate, thin skin around the eyes. Unlike traditional fillers, it does not aim to add artificial volume. Instead, it boosts the tissue’s own capacity to repair itself. Dr. Ömer Fatih Şahin’s Note: “Dark circles are not always caused by a ‘hollow’ that needs filling. Often, the issue is the thinning of the skin, making the underlying blood vessels visible. Rejuran I
solves this root cause naturally by thickening and strengthening the dermis.”
Mechanism of Action: How It Works
When injected, Rejuran I triggers four key biological processes in the eye area:
1. Dermis Thickening: It increases the density of the thin skin under the eyes, reducing the visibility of dark vessels underneath.
2. Collagen Synthesis: It activates fibroblast cells to tighten loose skin around the eyes.
3. Microcirculation Regulation: It revitalizes sluggish blood circulation, helping to reduce dark circles and puffiness.
4. Elasticity Improvement: It smooths out fine lines, often referred to as “crepey skin.”
Comparative Analysis: Rejuran I or Tear Trough Filler?
The most common question from our patients is: “Doctor, should I get filler or Rejuran for my eyes?”
These two treatments serve different needs. Here are the key differences:
● Primary Goal: Fillers aim to fill hollows. Rejuran I aims to repair thin skin, thicken the dermis, and treat dark circles biologically.
● Risk Factor: Fillers carry a risk of water retention (edema) and the Tyndall effect (bluish tint). Rejuran I is a biological healer; it does not cause edema and looks completely natural.
● Volume Effect: Fillers provide instant volume. Rejuran I does not add volume; it improves tissue quality.
● Appearance: Fillers can sometimes create a “puffy” look. Rejuran I maintains your natural eye structure while providing a rested, youthful appearance.
Functional Medicine & Holistic Approach
Dark circles and eye bags are not just aesthetic flaws; sometimes they are a cry for help from the body. When planning treatment at our clinic, we also consider:
● Iron Deficiency: Anemia is a leading cause of dark circles.
● Sleep & Stress: Fatigue and high cortisol impair lymphatic drainage.
● Kidney & Liver Load: Eye bags can sometimes indicate systemic edema.
● Allergies: Histamine release can darken the eye area.
Our aim is not just to inject, but to address the root cause of “tired eyes” for lasting wellness.
Who Is It Suitable For?
It is the ideal treatment for candidates with:
● Thin skin and visible veins under the eyes.
● Dark circles and pigmentation around the eyes.
● Crow’s feet and fine lines (crepey skin).
● A fear of tear trough fillers or those unsuitable for fillers.
● Previous bad experiences with fillers (e.g., persistent edema).
Frequently Asked Questions (FAQ)
Are Rejuran I and Rejuran Healer the same? While they contain the same ingredient (Polynucleotide), their viscosity differs. Rejuran I is more fluid and delicate, specifically produced to spread evenly in the thin skin around the eyes. Healer is denser and used for the rest of the face.
Is the procedure painful? The eye area is sensitive, but thanks to Dr. Ömer Fatih Şahin’s expertise in Anesthesiology, we use special numbing protocols to ensure the highest level of comfort during the procedure.
How many sessions are needed? Depending on the severity of the damage, we generally recommend a course of 3-4 sessions, spaced 2-3 weeks apart.
How long does it last? Since the result is your skin’s own repair, it is long-lasting. However, as the aging process continues, maintenance sessions are recommended every 6-9 months.
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Rejuran Healer

Rejuran Healer is a concentrated form of Polynucleotides (PN) derived from Pacific salmon DNA, which shows high compatibility with human DNA. It is not a filler. When injected into the skin, it acts as a bio-stimulator, repairing damaged tissue from within. Dr. Ömer Fatih Şahin’s Note: “Instead of adding a foreign substance to the skin, Rejuran acts like a project manager, waking up the ‘construction workers’ (fibroblasts) of your skin to start the repair process naturally.”
Mechanism of Action: How It Works
Rejuran Healer triggers four main biological processes:
1. ECM (Extracellular Matrix) Repair: It stabilizes and strengthens the scaffold of the skin.
2. Fibroblast Activation: It stimulates fibroblasts—the fountain of youth cells—to increase Type I and Type III collagen production.
3. Anti-Inflammatory Effect: It suppresses micro-inflammation in the skin, reducing redness and sensitivity.
4. Angiogenesis (Circulation Support): It regulates microcirculation, improving skin oxygenation and glow.
Comparative Analysis: Rejuran Healer or Dermal Fillers?
The most frequent question we hear is: “Doctor, is this a filler? Will it make my face puffy?” No, Rejuran Healer is not a filler. Here are the distinctions:
● Primary Goal: Fillers aim to fill voids and add volume. Rejuran Healer aims to improve skin quality and repair damage.
● Fillers can make areas look fuller. Rejuran Healer does not plump the face; it works on improving skin quality instead.
● Target Tissue: Fillers are often placed deep (on bone or fat pads). Rejuran is injected into the Dermis (the skin layer).
● Result Timeline: Fillers show instant results. Rejuran results appear gradually over 3-4 weeks as biological repair occurs.
● Look: Fillers provide contour. Rejuran provides tighter, smoother, and more radiant skin texture.
Functional Medicine & Holistic Approach
At our clinic, we don’t view Rejuran Healer merely as an injection. Skin quality is directly linked to gut health, sleep patterns, and stress levels.
We evaluate factors such as:
● Stress Management: High cortisol accelerates collagen breakdown.
● Nutrition: Sugar and processed foods age the skin via “Glycation.”
● Micronutrient Support: We ensure optimal vitamin/mineral balance to boost the effects of Rejuran.
Our goal is not temporary shine, but a biologically healthier and more resilient tissue environment.
Who Is It Suitable For? (Indications)
This protocol is ideal for individuals with:
● Skin that has lost elasticity and is prone to sagging.
● Enlarged pores and sebum (oil) imbalance.
● Acne scars (atrophic scars) and uneven skin texture.
● Dull, dehydrated, and “tired-looking” skin.
● Fine wrinkles starting to appear (especially on the neck and cheeks).
Frequently Asked Questions (FAQ)
Will Rejuran Healer change my face shape? No. Since it is not a filler, it does not alter your facial features or create puffiness. It simply improves the texture and youthfulness of your skin.
Is the procedure painful? The treatment involves micro-injections. Thanks to Dr. Ömer Fatih Şahin’s Anesthesiology background, pain management and patient comfort are maximized through special pre-procedure protocols.
Can it be done in summer? Yes. Rejuran does not cause photosensitivity (sun sensitivity). On the contrary, because it strengthens the skin barrier, it is a safe and excellent choice before or after summer to repair sun damage.
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PN (Polynucleotide Salmon DNA)

PN (Polynucleotide) represents the “Gold Standard” in regenerative medicine. Derived from Salmon DNA, these long-chain molecules are certified as Class III Medical Devices, ensuring superior safety and potency compared to standard cosmetics. It is the preferred protocol in our Nişantaşı, Istanbul clinic for treating dark circles, neck lines, and skin laxity without artificial volume.
What Is PN Therapy?
While PDRN repairs the surface, PN builds the structure. It creates a 3D biological scaffold within the skin, stimulating fibroblasts to produce high-quality collagen.
Why Choose PN?
● Deep Regeneration: Reaches deeper layers than PDRN.
● Lifting Effect: Its high viscosity provides a natural tightening effect.
● Medical Safety: Being a Class III Medical Device, it meets the strictest safety regulations for injectables.
Where Does It Work Best?
1. Under-Eyes It thickens the dermis to hide dark circles and veins, without the risk of water retention (edema) common with HA fillers.
2. Neck & Décolleté Effectively targets deep horizontal lines (“Tech-Neck”) and restores skin density.
3. Full Face Lifting Tightens pores and lifts sagging skin, creating a firm and youthful texture.
The Procedure in Istanbul
1. Application: Performed using micro-injections or a cannula after numbing cream. Takes 20 minutes.
2. Protocol: We recommend 3 sessions, spaced 2–3 weeks apart, for a complete biological reset.
Frequently Asked Questions (FAQ)
1. Is PN better than PDRN ? Yes, for structural aging. PN is the stronger, medical-grade evolution of
PDRN. If you need lifting and deep repair, PN is the superior choice.
2. Is it a Filler? No. It does not add artificial volume. It restores your skin’s own volume by
regenerating tissue. You will look like “you,” just fresher.
3. What does “Class III” mean? It means the product is not just a cosmetic serum but a certified
Medical Device authorized for deep injection. This guarantees purity, sterility, and efficacy.
4. When will I see results? Texture improves after the first session. Significant lifting and elasticity
improvements are visible after the 2nd session and peak around month 3.
5. What is the cost in Istanbul? Prices depend on the brand (e.g., Plinest, Newest) and number of
sessions. Treatment in Turkey offers premium medical aesthetics at a competitive price.
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Plinest & Newest PN Therapy

Plinest and Newest are advanced biostimulators based on Polynucleotide (PN) technology derived from Salmon DNA. They serve to regenerate skin
at the cellular level. At our Nişantaşı, Istanbul clinic, we utilize Plinest Eye for dark circles, Plinest for deep repair, and Newest for intense hydration and glow.
What Is the Plinest Family? (PN Technology)
As we age, our skin’s DNA repair capacity diminishes. The Plinest family uses Polynucleotides (PN) to signal skin cells to “repair and regenerate.” Unlike standard
mesotherapy, it doesn’t just nourish; it biologically stimulates fibroblasts to restore skin structure.
The Product Range & Indications
Dr. Ömer Fatih Şahin selects the specifically tailored product based on your skin concern:
1. Plinest (Classic): “The Restorer”
Contains the highest concentration of Polynucleotides. It comes in a 2ml syringe and contains 40 mg of PN.
● Target: Deep tissue repair and firming.
● Best For: Acne scars, enlarged pores, stretch marks, and loss of elasticity. It aims to thicken and strengthen the skin.
2. Plinest Eye: “The Eye Specialist”
Designed to support regeneration in thin and sensitive periocular skin. It comes in a 2ml syringe and contains 15 mg of PN.
● Target: Eye area restructuring.
● Best For: Dark circles, puffiness, fine lines, and “tired eyes.” It is a safe biological alternative for those avoiding under-eye fillers.
3. Newest: “The Glow Booster”
A powerful combination of Polynucleotides (PN) + Hyaluronic Acid (HA) + Mannitol. It comes
in a 2ml syringe and contains 20 mg PN and 20 mg HA.
● Target: Repair + Intense Hydration.
● Best For: Dry, dull skin, and the neck/décolleté area. It provides an immediate
“moisture bomb” effect for a radiant glow.
The Procedure in Istanbul
1. Application: Performed using micro-injections or a cannula after applying numbing cream. The session takes about 15–20 minutes.
2. Protocol: We typically recommend 3 to 4 sessions, spaced 2–3 weeks apart, depending on skin condition.
Frequently Asked Questions (FAQ)
1. Can I have this if I have a fish allergy? The products are derived from salmon DNA.
Although highly purified, we generally do not recommend it for patients with severe fish
allergies as a precaution.
2. Is it a Filler? Will my face look swollen? No. None of these products add artificial
volume. Your face will not look swollen or changed. They simply improve the quality,
firmness, and health of your skin.
3. What is the difference between Newest and Plinest?
● Plinest: Pure PN. Focuses on firming and scar repair.
● Newest: PN + Hyaluronic Acid. Focuses on hydration and glow. Your doctor will
decide which one suits your skin type best.
4. When will I see results? You will feel hydration and skin relief after the first session.
Significant structural repair and pore tightening typically become visible after the 2nd
session.
5. Is there downtime? Minimal. You might have tiny bumps or minor bruising at the injection
sites for 24 hours. You can return to your social life immediately.
6. What is the cost in Istanbul? Prices depend on the specific product (Eye, Newest, etc.)
and the number of sessions. Treatment in Turkey offers premium quality at a competitive
price.
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PDRN (Salmon DNA)

PDRN (Polydeoxyribonucleotide) is widely known as “Salmon DNA” and is used for surface skin healing and hydration. However, modern aesthetic medicine has evolved
towards PN (Polynucleotide) therapy. While PDRN is effective for mild hydration, our clinic primarily recommends Class III Medical Device certified PN treatments for true structural remodeling and anti-aging.
What Is PDRN?
PDRN consists of short DNA fragments derived from Salmon. It has been used for years to help heal diabetic wounds. In aesthetics, it is used as a “skin booster” to provide moisture and reduce redness.
How It Works: It binds to receptors on cells to lower inflammation and encourage mild healing. It gives the skin a temporary “fresh” look.
The Critical Difference: PDRN vs. PN
This is the most important distinction for patients to understand. In the medical world, the safety and potency of an injectable are defined by its classification.
1. PDRN (Short Chain): Often found in cosmetic mesotherapy cocktails. It nourishes the skin surface but lacks the strength to build structure. It is a “polishing” treatment.
2. PN (Polynucleotide – Long Chain): This is the purified, high-molecular-weight, and Class III Medical Device certified evolution of PDRN. When injected, it acts like a scaffold, lifting the tissue and stimulating deep collagen production.
Summary: PDRN is the “bandage,” PN is the “architect.”
Who Should Choose PDRN?
If you are not looking for deep anti-aging or lifting, but simply want to refresh your skin, PDRN might be an option:
● Superficial dryness and dullness.
● Mild redness or sensitive skin conditions.
● Entry-level skin maintenance.
However; for dark circles, neck lines, skin laxity (sagging), and deep acne scars, PN
(Polynucleotide) therapy is medically superior and more effective.
The Procedure in Istanbul
1. Application: PDRN is a fluid solution injected into the upper skin layers using mesotherapy techniques.
2. Comfort: It is a quick, 15-minute procedure with minimal discomfort using numbing cream.
3. Protocol: Usually requires 3-4 sessions spaced 2 weeks apart.
Frequently Asked Questions (FAQ)
1. Is PN better than PDRN? In most cases, yes. PN is the stronger, longer-lasting, and more
medically advanced version of PDRN. If you want a real biological investment in your skin structure,
Dr. Şahin recommends PN protocols (like Plinest/Newest).
2. Is PDRN a filler? No. It does not volumize the face. It only hydrates and soothes the skin.
3.3. Understanding Class III medical device classification and its clinical significance
Class III represents the highest safety standard for injectable medical devices in Europe and Turkey.
While many PDRN products are simple cosmetics, premium PN products are certified Medical
Devices, ensuring purity and safety.
4. How long do results last? PDRN results (glow and hydration) typically last 3–6 months. Since
PN rebuilds the tissue, its results can persist for 9–12 months.
5. Is there a price difference? Yes. PN products are more expensive due to their advanced
manufacturing technology and medical certification (Class III). However, they offer a much higher
value in terms of visible results and longevity.
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