Commonly known as “Rejuran Eye,” Rejuran I is a specialized formulation of Polynucleotides (PN) derived from wild salmon DNA. It is specifically designed for the delicate, thin skin around the eyes. Unlike traditional fillers, it does not aim to add artificial volume. Instead, it boosts the tissue’s own capacity to repair itself. Dr. Ömer Fatih Şahin’s Note: “Dark circles are not always caused by a ‘hollow’ that needs filling. Often, the issue is the thinning of the skin, making the underlying blood vessels visible. Rejuran I
solves this root cause naturally by thickening and strengthening the dermis.”

Mechanism of Action: How It Works
When injected, Rejuran I triggers four key biological processes in the eye area:
1. Dermis Thickening: It increases the density of the thin skin under the eyes, reducing the visibility of dark vessels underneath.
2. Collagen Synthesis: It activates fibroblast cells to tighten loose skin around the eyes.
3. Microcirculation Regulation: It revitalizes sluggish blood circulation, helping to reduce dark circles and puffiness.
4. Elasticity Improvement: It smooths out fine lines, often referred to as “crepey skin.”
Comparative Analysis: Rejuran I or Tear Trough Filler?
The most common question from our patients is: “Doctor, should I get filler or Rejuran for my eyes?”
These two treatments serve different needs. Here are the key differences:
● Primary Goal: Fillers aim to fill hollows. Rejuran I aims to repair thin skin, thicken the dermis, and treat dark circles biologically.
● Risk Factor: Fillers carry a risk of water retention (edema) and the Tyndall effect (bluish tint). Rejuran I is a biological healer; it does not cause edema and looks completely natural.
● Volume Effect: Fillers provide instant volume. Rejuran I does not add volume; it improves tissue quality.
● Appearance: Fillers can sometimes create a “puffy” look. Rejuran I maintains your natural eye structure while providing a rested, youthful appearance.
Functional Medicine & Holistic Approach
Dark circles and eye bags are not just aesthetic flaws; sometimes they are a cry for help from the body. When planning treatment at our clinic, we also consider:
● Iron Deficiency: Anemia is a leading cause of dark circles.
● Sleep & Stress: Fatigue and high cortisol impair lymphatic drainage.
● Kidney & Liver Load: Eye bags can sometimes indicate systemic edema.
● Allergies: Histamine release can darken the eye area.
Our aim is not just to inject, but to address the root cause of “tired eyes” for lasting wellness.
Who Is It Suitable For?
It is the ideal treatment for candidates with:
● Thin skin and visible veins under the eyes.
● Dark circles and pigmentation around the eyes.
● Crow’s feet and fine lines (crepey skin).
● A fear of tear trough fillers or those unsuitable for fillers.
● Previous bad experiences with fillers (e.g., persistent edema).
Frequently Asked Questions (FAQ)
Are Rejuran I and Rejuran Healer the same? While they contain the same ingredient (Polynucleotide), their viscosity differs. Rejuran I is more fluid and delicate, specifically produced to spread evenly in the thin skin around the eyes. Healer is denser and used for the rest of the face.
Is the procedure painful? The eye area is sensitive, but thanks to Dr. Ömer Fatih Şahin’s expertise in Anesthesiology, we use special numbing protocols to ensure the highest level of comfort during the procedure.
How many sessions are needed? Depending on the severity of the damage, we generally recommend a course of 3-4 sessions, spaced 2-3 weeks apart.

How long does it last? Since the result is your skin’s own repair, it is long-lasting. However, as the aging process continues, maintenance sessions are recommended every 6-9 months.