Salmon DNA Applications arşivleri - Uzm. Dr. Ömer Fatih Şahin

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PN (Polynucleotide) represents the “Gold Standard” in regenerative medicine. Derived from Salmon DNA, these long-chain molecules are certified as Class III Medical Devices, ensuring superior safety and potency compared to standard cosmetics. It is the preferred protocol in our Nişantaşı, Istanbul clinic for treating dark circles, neck lines, and skin laxity without artificial volume.
What Is PN Therapy?
While PDRN repairs the surface, PN builds the structure. It creates a 3D biological scaffold within the skin, stimulating fibroblasts to produce high-quality collagen.
Why Choose PN?
● Deep Regeneration: Reaches deeper layers than PDRN.
● Lifting Effect: Its high viscosity provides a natural tightening effect.
● Medical Safety: Being a Class III Medical Device, it meets the strictest safety regulations for injectables.
Where Does It Work Best?
1. Under-Eyes It thickens the dermis to hide dark circles and veins, without the risk of water retention (edema) common with HA fillers.
2. Neck & Décolleté Effectively targets deep horizontal lines (“Tech-Neck”) and restores skin density.
3. Full Face Lifting Tightens pores and lifts sagging skin, creating a firm and youthful texture.
The Procedure in Istanbul
1. Application: Performed using micro-injections or a cannula after numbing cream. Takes 20 minutes.
2. Protocol: We recommend 3 sessions, spaced 2–3 weeks apart, for a complete biological reset.
Frequently Asked Questions (FAQ)
1. Is PN better than PDRN ? Yes, for structural aging. PN is the stronger, medical-grade evolution of
PDRN. If you need lifting and deep repair, PN is the superior choice.
2. Is it a Filler? No. It does not add artificial volume. It restores your skin’s own volume by
regenerating tissue. You will look like “you,” just fresher.

3. What does “Class III” mean? It means the product is not just a cosmetic serum but a certified
Medical Device authorized for deep injection. This guarantees purity, sterility, and efficacy.
4. When will I see results? Texture improves after the first session. Significant lifting and elasticity
improvements are visible after the 2nd session and peak around month 3.
5. What is the cost in Istanbul? Prices depend on the brand (e.g., Plinest, Newest) and number of
sessions. Treatment in Turkey offers premium medical aesthetics at a competitive price.

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Plinest and Newest are advanced biostimulators based on Polynucleotide (PN) technology derived from Salmon DNA. They serve to regenerate skin
at the cellular level. At our Nişantaşı, Istanbul clinic, we utilize Plinest Eye for dark circles, Plinest for deep repair, and Newest for intense hydration and glow.

What Is the Plinest Family? (PN Technology)
As we age, our skin’s DNA repair capacity diminishes. The Plinest family uses Polynucleotides (PN) to signal skin cells to “repair and regenerate.” Unlike standard
mesotherapy, it doesn’t just nourish; it biologically stimulates fibroblasts to restore skin structure.
The Product Range & Indications
Dr. Ömer Fatih Şahin selects the specifically tailored product based on your skin concern:
1. Plinest (Classic): “The Restorer”
Contains the highest concentration of Polynucleotides. It comes in a 2ml syringe and contains 40 mg of PN.
● Target: Deep tissue repair and firming.
● Best For: Acne scars, enlarged pores, stretch marks, and loss of elasticity. It aims to thicken and strengthen the skin.
2. Plinest Eye: “The Eye Specialist”
Designed to support regeneration in thin and sensitive periocular skin. It comes in a 2ml syringe and contains 15 mg of PN.
● Target: Eye area restructuring.
● Best For: Dark circles, puffiness, fine lines, and “tired eyes.” It is a safe biological alternative for those avoiding under-eye fillers.
3. Newest: “The Glow Booster”

A powerful combination of Polynucleotides (PN) + Hyaluronic Acid (HA) + Mannitol. It comes
in a 2ml syringe and contains 20 mg PN and 20 mg HA.
● Target: Repair + Intense Hydration.
● Best For: Dry, dull skin, and the neck/décolleté area. It provides an immediate
“moisture bomb” effect for a radiant glow.
The Procedure in Istanbul
1. Application: Performed using micro-injections or a cannula after applying numbing cream. The session takes about 15–20 minutes.
2. Protocol: We typically recommend 3 to 4 sessions, spaced 2–3 weeks apart, depending on skin condition.

Frequently Asked Questions (FAQ)
1. Can I have this if I have a fish allergy? The products are derived from salmon DNA.
Although highly purified, we generally do not recommend it for patients with severe fish
allergies as a precaution.
2. Is it a Filler? Will my face look swollen? No. None of these products add artificial
volume. Your face will not look swollen or changed. They simply improve the quality,
firmness, and health of your skin.
3. What is the difference between Newest and Plinest?
● Plinest: Pure PN. Focuses on firming and scar repair.
● Newest: PN + Hyaluronic Acid. Focuses on hydration and glow. Your doctor will
decide which one suits your skin type best.
4. When will I see results? You will feel hydration and skin relief after the first session.
Significant structural repair and pore tightening typically become visible after the 2nd
session.
5. Is there downtime? Minimal. You might have tiny bumps or minor bruising at the injection
sites for 24 hours. You can return to your social life immediately.
6. What is the cost in Istanbul? Prices depend on the specific product (Eye, Newest, etc.)
and the number of sessions. Treatment in Turkey offers premium quality at a competitive
price.

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PDRN (Polydeoxyribonucleotide) is widely known as “Salmon DNA” and is used for surface skin healing and hydration. However, modern aesthetic medicine has evolved
towards PN (Polynucleotide) therapy. While PDRN is effective for mild hydration, our clinic primarily recommends Class III Medical Device certified PN treatments for true structural remodeling and anti-aging.
What Is PDRN?
PDRN consists of short DNA fragments derived from Salmon. It has been used for years to help heal diabetic wounds. In aesthetics, it is used as a “skin booster” to provide moisture and reduce redness.
How It Works: It binds to receptors on cells to lower inflammation and encourage mild healing. It gives the skin a temporary “fresh” look.
The Critical Difference: PDRN vs. PN
This is the most important distinction for patients to understand. In the medical world, the safety and potency of an injectable are defined by its classification.
1. PDRN (Short Chain): Often found in cosmetic mesotherapy cocktails. It nourishes the skin surface but lacks the strength to build structure. It is a “polishing” treatment.
2. PN (Polynucleotide – Long Chain): This is the purified, high-molecular-weight, and Class III Medical Device certified evolution of PDRN. When injected, it acts like a scaffold, lifting the tissue and stimulating deep collagen production.
Summary: PDRN is the “bandage,” PN is the “architect.”
Who Should Choose PDRN?
If you are not looking for deep anti-aging or lifting, but simply want to refresh your skin, PDRN might be an option:
● Superficial dryness and dullness.

● Mild redness or sensitive skin conditions.
● Entry-level skin maintenance.
However; for dark circles, neck lines, skin laxity (sagging), and deep acne scars, PN
(Polynucleotide) therapy is medically superior and more effective.
The Procedure in Istanbul
1. Application: PDRN is a fluid solution injected into the upper skin layers using mesotherapy techniques.
2. Comfort: It is a quick, 15-minute procedure with minimal discomfort using numbing cream.
3. Protocol: Usually requires 3-4 sessions spaced 2 weeks apart.
Frequently Asked Questions (FAQ)
1. Is PN better than PDRN? In most cases, yes. PN is the stronger, longer-lasting, and more
medically advanced version of PDRN. If you want a real biological investment in your skin structure,
Dr. Şahin recommends PN protocols (like Plinest/Newest).
2. Is PDRN a filler? No. It does not volumize the face. It only hydrates and soothes the skin.
3.3. Understanding Class III medical device classification and its clinical significance
Class III represents the highest safety standard for injectable medical devices in Europe and Turkey.
While many PDRN products are simple cosmetics, premium PN products are certified Medical
Devices, ensuring purity and safety.
4. How long do results last? PDRN results (glow and hydration) typically last 3–6 months. Since
PN rebuilds the tissue, its results can persist for 9–12 months.
5. Is there a price difference? Yes. PN products are more expensive due to their advanced
manufacturing technology and medical certification (Class III). However, they offer a much higher
value in terms of visible results and longevity.

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