Alloblast is the application to the skin of fibroblasts — the skin cells that produce collagen and elastin — obtained from neonatal tissue and expanded in a laboratory. Because the cells come from a donor rather than from the person being treated, they are called “allogeneic”. It is a ready product: no biopsy and no laboratory waiting period are needed, and the application is completed in a single session. It is not a filler: its aim is not to add volume, and it does not change the shape of the face. The target is skin quality.
I am a specialist in anaesthesiology and reanimation; sterile technique and injection safety are core areas of my training. I perform cellular treatments within this framework, carrying out every step of preparation and application myself. The general framework of cellular treatments is on the cellular therapies page.
It is not a stem cell treatment
Alloblast is a fibroblast treatment, not a stem cell treatment. A fibroblast is a mature skin cell and does not turn into another cell type. The product falls into the class of advanced therapy medicinal products (ATMP), a class covering cell- or tissue-based products subject to specific regulations. I state this distinction explicitly, because the name “stem cell” is used incorrectly for this treatment.
How is it thought to work?
The number and productive capacity of fibroblasts in the skin decline with age; as the extracellular matrix weakens, loss of elasticity and surface irregularity appear. In Alloblast, the aim is for the fibroblasts delivered into the skin to contribute to this production. According to the manufacturer, the applied cells support collagen and elastin production; I could not find an independent human study for this mechanism, so I give no numerical values and set out the level of evidence separately below.
Process and session plan
- Preparation. The skin is disinfected; topical anaesthetic cream is applied.
- Product preparation. The product arrives in the cold chain and is opened on the day of treatment.
- Application. The product is delivered with very fine needles, leaving small blebs within the skin (intradermal papule technique). Cannulas are not used.
- Duration. The whole procedure takes about 30 minutes.
I plan it as a single session; I decide at consultation whether repetition is needed. The effect is not immediate: radiance is reported within weeks, and change in skin quality within months. There are no independent data beyond the manufacturer’s statement on how long the effect lasts, so I give no figures for duration.
When do I consider it?
Conditions I assess in my clinical practice:
- Wrinkles, loss of elasticity and fine lines
- General loss of skin quality, dullness and uneven tone
- Superficial acne scars — I do not promise that it is sufficient on its own for deep pitted scars
- Neck, décolletage and the back of the hands; region-specific assessment is on the neck and décolletage rejuvenation and hand rejuvenation pages
I do not recommend this method to someone whose goal is volume or shape.
How it differs from treatment with your own cells
I do not steer people towards Alloblast because it is ready and single-session; I explain it alongside the autologous method according to the goal and the expected timeline, and I make the decision at consultation.
With fibroblast treatment, the decision depends on the source and the timeline: working with your own cells requires a biopsy and weeks of culture; when a ready product and a single session are preferred, allogeneic fibroblasts come to the fore. The final choice is made at consultation.
Treatment with your own cells is described on the autologous fibroblast therapy page; cell-free options are on the exosome page.
Being honest about the level of evidence
I could not find an independent, controlled human study showing the effect of allogeneic fibroblast treatment on skin quality; current knowledge rests on manufacturer data and observational reports. Placebo-controlled randomised trials exist for cultured autologous fibroblasts, but I do not transfer that evidence to Alloblast — different source, different product. For this reason I give no percentages or durations when describing Alloblast, and I discuss expectations openly from the outset.
The procedure and pain management
Topical anaesthetic cream is standard. Because I am an anaesthesiologist, I treat pain management as a separate part of the procedure.
Cooling is added when needed; what you feel is a brief sting and mild burning.
Aftercare
First 24 hours
- No make-up on the treated area
- No hot showers, sauna, hammam or steam
- Avoid heavy exercise
- No alcohol
- Do not sleep face-down (facial treatments)
- Do not touch the injection points; do not squeeze or massage the bumps
First 48 hours
- Avoid direct and prolonged sun exposure
- No facial massage, skincare treatments or energy-based device treatments
Expected findings Small bumps (papules) at the injection points lasting 12–24 hours are expected and show that the product has settled in the skin. Mild swelling, tenderness or bruising lasting a few days may occur. Around the eyes, bruising is slightly more likely than on the rest of the face.
Additional advice
- No cosmetic products on the treated area for the first 3 days; no heavy exercise in the first week
- No deep-tissue laser or aggressive peeling to the area for the first 3 months
- If redness increases, or warmth or fever develops, contact the clinic
Safety and anatomy
Because allergic reactions can occur rarely, treatments are carried out under medical supervision.
The product is transported in the cold chain and opened on the day of treatment. The small blebs left within the skin, temporary redness and bruising may occur; the expected durations are given in the aftercare section. Treatment is postponed if there is an active infection in the area.
Manufacturing and regulatory status: I obtain the Alloblast products I use from accredited laboratories that hold a cGMP production permit approved by the Turkish Medicines and Medical Devices Agency (TİTCK) of the Ministry of Health. The laboratories’ operating status can be checked on TİTCK’s manufacturer and distributor search page. Approval belongs to a product and to a specific indication, not to a technique or to a physician.
Who is not suitable
Treatment is not performed, or is postponed, in the following situations:
- Active infection or inflammation in the treatment area
- Autoimmune disease in an active phase
- Pregnancy and breastfeeding
- Known hypersensitivity to the product components
- Uncontrolled chronic illness
- Untreated bleeding disorder or unregulated anticoagulant use
I do not perform these treatments during active cancer treatment. For a person with a history of cancer, I make the decision together with the treating specialist.
For a person on immunosuppressive treatment, the decision is made at consultation.
Treatment is postponed during an active cold sore (herpes) outbreak in the area, during an active acne flare, and if aggressive peeling or laser was performed on the same area within the past two weeks.
Without being a medical contraindication, I also consider expectation and treatment to be mismatched in these situations:
- People expecting a marked and lasting change from a single session
- People whose actual need is a change in volume or shape — filler is assessed
- People who prefer not to be treated with a product other than their own cells — in that case the autologous method is discussed
Suitability is determined by consultation in every case.
Pricing
Under the applicable regulations, price information cannot be published on our website. The cost of a treatment depends on the product used, the technique chosen and the extent of the treatment. You can call the clinic for detailed information.
Frequently asked questions
Is Alloblast a stem cell treatment?
No. Alloblast is a fibroblast treatment; a fibroblast is a mature skin cell and does not turn into another cell type.
How many Alloblast sessions are needed?
I plan it as a single session. I decide at consultation whether repetition is needed; I do not give a schedule.
Is there a cancer risk with Alloblast?
Fibroblasts are mature (somatic) cells; the laboratory only increases their number and does not alter their genetic makeup. I do not perform this treatment during active cancer treatment; with a history of cancer, I make the decision together with the treating specialist.
Which areas can be treated with Alloblast?
The face; the neck, décolletage and the back of the hands can also be treated. I assess suitability by area at consultation.
Planning your visit
My clinic is in Nişantaşı, Şişli, on the European side of Istanbul, approximately 45 minutes from Istanbul Airport.
For Alloblast I suggest planning a stay of two to three days: arrival, consultation and treatment, and departure. The product is ordered in advance, so please book before travelling. Flying is generally appropriate 24 hours after an injectable treatment.
Consultations are conducted in English. Follow-up after you return home is arranged remotely, and I remain reachable for any questions during the period in which the result develops.
Dr. Ömer Fatih Şahin — Specialist in Anaesthesiology and Reanimation Diploma Registration No: 113606
Published: 22 February 2026 · Last updated: 2026-09-21 This content has been medically reviewed by Dr. Ömer Fatih Şahin.